NEXN

Across TCGA cell cohorts, NEXN mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEXN-associated genes across cancer lineages are ASB17, OR5H2, and OR2C1. Each is linked with NEXN in more than 1 cancer types. Because this analysis shows association rather than direction, both NEXN-to-partner and partner-to-NEXN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by NEXN-low versus NEXN-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEXN→partner) and Y-score (partner→NEXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	2
STOMACH	OR5H2 →	+0.276	+5.285	<.001	.003	3	1
LARGE_INTESTINE	OR2C1 →	+0.098	+3.725	.003	.008	3	1
LARGE_INTESTINE	SPATA8 →	+0.284	+3.347	.001	.005	3	1
LARGE_INTESTINE	CCL18 →	+0.066	+4.415	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ASB17 by NEXN expression — OVARY

Explore this box plot interactively →