NEXN-AS1

Across TCGA pan-cancer cohorts, NEXN-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated NEXN-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NEXN-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NEXN-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and BRCA show a favorable association.

KIRC, UVM, and UCS are the cancer types where NEXN-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.412	0.623	<.001	86	view →
UVM	OS	Median	III,IV	0.399	0.794	.001	52	view →
UCS	DFS	Median	II,III,IV	0.626	0.246	<.001	46	view →
BRCA	OS	Median	III,IV	0.888	0.775	.004	43	view →
LGG	DFS	Median	All	0.640	0.824	<.001	40	view →
UCEC	DFS	Tertile	All	0.782	0.862	.015	26	view →
SKCM	OS	Median	II,III,IV	0.476	0.282	.002	24	view →
LIHC	OS	Tertile	All	0.673	0.840	.003	21	view →
CESC	DFS	Tertile	III,IV	0.524	0.831	.006	18	view →
THCA	OS	Tertile	II,III,IV	0.946	0.994	.010	16	view →
LAML	DFS	Median	All	0.454	0.694	.009	8	view →
OV	OS	Tertile	III,IV	0.803	0.863	.030	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

NEXN-AS1–KIRC (DFS)

Open the KIRC breakdown →