NEXN-AS1

Across TCGA pan-cancer cohorts, NEXN-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NEXN-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NEXN-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types NEXN-AS1 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, LUSC, and KIRC are the cancer types where NEXN-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NEXN-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.694	<.001	9	view →
LUSC	Male	III,IV	−0.350	<.001	8	view →
KIRC	All	III,IV	−0.116	.007	5	view →
BRCA	All	All	−0.170	<.001	4	view →
LIHC	All	All	+0.081	.002	4	view →
UCEC	All	All	−0.357	.005	2	view →
BLCA	All	All	−0.322	.034	2	view →
CHOL	All	All	+0.535	.018	1	view →
READ	Female	All	−0.270	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

NEXN-AS1–THCA

Open the THCA breakdown →