NEXMIF

Across TCGA pan-cancer cohorts, NEXMIF Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated NEXMIF data layer compared with 28 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NEXMIF Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated NEXMIF expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, KIRC, and SKCM are the cancer types where NEXMIF Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.887	0.420	.005	36	view →
KIRC	DFS	Median	IV	0.205	0.603	.001	30	view →
SKCM	OS	Median	II,III,IV	0.864	0.691	<.001	21	view →
LIHC	OS	Median	All	0.258	0.778	<.001	15	view →
CESC	DFS	Median	II,III,IV	1.000	0.670	.025	12	view →
STAD	DFS	Median	II,III,IV	0.921	0.595	.033	9	view →
ESCA	OS	Median	II,III,IV	0.109	0.931	.003	9	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SCLC	DFS	Median	II,III,IV	0.219	0.609	.016	6	view →
LGG	DFS	Median	All	0.192	0.728	.007	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

NEXMIF–UCEC (DFS)

Open the UCEC breakdown →