NEUROG3

Across TCGA patient cohorts, NEUROG3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,619 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible NEUROG3-associated GO terms across cancer lineages are Lymphocyte activation involved in immune response, Marginal zone B cell differentiation, and Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation. Each is linked with NEUROG3 in more than 12 cancer types. Because this analysis shows association rather than direction, both NEUROG3-to-partner and partner-to-NEUROG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lymphocyte activation involved in immune response grouped by NEUROG3-low versus NEUROG3-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NEUROG3→partner) and Y-score (partner→NEUROG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Lymphocyte activation involved in immune response →	+0.037	+0.856	<.001	.003	3	12
ESCA	Marginal zone B cell differentiation →	+0.087	+0.914	<.001	.003	2	13
ESCA	Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation →	+0.081	+1.124	<.001	<.001	3	12
UVM	Secretion of lysosomal enzymes →	+0.039	+0.060	<.001	.002	3	12
MESO	Negative regulation of antigen receptor-mediated signaling pathway →	+0.056	+0.495	<.001	<.001	3	12
SKCM	Alpha-beta T cell proliferation →	+0.061	+0.330	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,619 associations by consensus.

Lymphocyte activation involved in immune response by NEUROG3 expression — ESCA

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