NEUROD6

Across TCGA patient cohorts, NEUROD6 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible NEUROD6-associated genes across cancer lineages are Syk, Gab2, and p27_pT198. Each is linked with NEUROD6 in more than 2 cancer types. Because this analysis shows association rather than direction, both NEUROD6-to-partner and partner-to-NEUROD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Syk grouped by NEUROD6-low versus NEUROD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEUROD6→partner) and Y-score (partner→NEUROD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Syk →	+0.375	+1.713	.018	.027	3	2
LUSC	Gab2 →	+0.456	+2.816	.036	.036	3	1
LUSC	p27_pT198 →	+0.203	+2.816	.012	.036	1	3
LUSC	beta-Catenin →	+0.562	+2.816	.047	.036	3	1
UCEC	MEK1 →	+0.342	+2.321	.027	.034	3	1
UCEC	4E-BP1_pT37_T46 →	-0.469	-3.308	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Syk by NEUROD6 expression — UCEC

Explore this box plot interactively →