NEUROD6

Across TCGA cell cohorts, NEUROD6 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEUROD6-associated genes across cancer lineages are RETNLB, IFNA2, and IZUMO3. Each is linked with NEUROD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEUROD6-to-partner and partner-to-NEUROD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RETNLB grouped by NEUROD6-low versus NEUROD6-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEUROD6→partner) and Y-score (partner→NEUROD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RETNLB →	+0.041	+5.169	<.001	.005	3	1
BREAST	IFNA2 →	+0.036	+5.169	<.001	.005	3	1
BREAST	IZUMO3 →	+0.035	+5.169	<.001	.005	3	1
LARGE_INTESTINE	BPIFB6 →	+0.014	+3.700	<.001	.009	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TECRL →	+0.012	+3.562	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

RETNLB by NEUROD6 expression — BREAST

Explore this box plot interactively →