NEUROD4

Across TCGA cell cohorts, NEUROD4 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible NEUROD4-associated genes across cancer lineages are DNAAF6, OR6X1, and FCAMR. Each is linked with NEUROD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEUROD4-to-partner and partner-to-NEUROD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAAF6 grouped by NEUROD4-low versus NEUROD4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEUROD4→partner) and Y-score (partner→NEUROD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DNAAF6 →	+0.032	+3.693	.002	.009	3	2
BLOOD_Myeloma	OR6X1 →	+0.020	+4.807	<.001	.006	3	1
SKIN	FCAMR →	+0.066	+3.554	<.001	.007	3	1
SKIN	MBD3L5 →	+0.021	+4.415	<.001	<.001	3	1
BLOOD_Leukemia	BPIFB6 →	+0.047	+4.969	<.001	.003	3	1
BLOOD_Leukemia	C3orf85 →	+0.044	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

DNAAF6 by NEUROD4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →