NEUROD4

Across TCGA pan-cancer cohorts, NEUROD4 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated NEUROD4 data layer compared with 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NEUROD4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NEUROD4 expression acts as an unfavorable survival marker, although some lineages such as LGG and HNSC show a favorable association.

UCEC, KIRP, and LUSC are the cancer types where NEUROD4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.710	0.862	<.001	96	view →
KIRP	OS	Tertile	All	0.423	0.743	<.001	93	view →
LUSC	DFS	Tertile	III,IV	0.261	0.549	.010	69	view →
LUAD	OS	Tertile	III,IV	0.417	0.687	.012	54	view →
KIRC	DFS	Quartile	All	0.452	0.664	<.001	47	view →
LGG	DFS	Median	All	0.811	0.663	<.001	42	view →
HNSC	OS	Tertile	IV	0.857	0.684	.016	36	view →
BLCA	OS	Tertile	II,III,IV	0.765	0.575	.005	33	view →
PAAD	DFS	Tertile	All	0.589	0.207	.012	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
SKCM	DFS	Tertile	All	0.756	0.591	.017	9	view →
GBM	DFS	Tertile	All	0.392	0.181	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

NEUROD4–UCEC (DFS)

Open the UCEC breakdown →