NEUROD1

Across TCGA patient cohorts, NEUROD1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEUROD1-associated genes across cancer lineages are eIF4E, ERK2, and PCNA. Each is linked with NEUROD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NEUROD1-to-partner and partner-to-NEUROD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NEUROD1-low versus NEUROD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEUROD1→partner) and Y-score (partner→NEUROD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.183	+3.183	.021	.009	3	3
UCEC	ERK2 →	+0.213	+2.222	.003	.010	3	3
UCEC	PCNA →	+0.223	+2.321	.005	.033	3	3
UCEC	Cyclin-B1 →	+0.688	+2.662	.001	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.176	-1.874	.005	.049	3	2
UCEC	Rab25 →	-0.298	-3.321	.016	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eIF4E by NEUROD1 expression — UCEC

Explore this box plot interactively →