NEUROD1

Across TCGA pan-cancer cohorts, NEUROD1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NEUROD1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NEUROD1 RNA is repressed in tumor relative to normal tissue. In most cancer types NEUROD1 is over-expressed in tumor, although a few such as COAD and KIRC show the opposite, repressed pattern.

COAD, KIRC, and KIRP are the cancer types where NEUROD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NEUROD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	−1.188	<.001	10	view →
KIRC	Male	All	−0.070	<.001	9	view →
KIRP	Male	III,IV	−0.091	<.001	8	view →
READ	All	All	−1.380	<.001	5	view →
STAD	Male	IV	−0.754	.003	3	view →
KICH	All	All	−0.062	.012	2	view →
LUAD	Female	II,III,IV	−0.048	<.001	2	view →
LUSC	All	All	−0.016	.002	2	view →
ESCA	All	All	−0.991	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

NEUROD1–COAD

Open the COAD breakdown →