NEUROD1

Across TCGA cell cohorts, NEUROD1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEUROD1-associated genes across cancer lineages are SENP3, CPLX4, and FBXW10. Each is linked with NEUROD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEUROD1-to-partner and partner-to-NEUROD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SENP3 grouped by NEUROD1-low versus NEUROD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEUROD1→partner) and Y-score (partner→NEUROD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SENP3 →	+0.548	+3.067	.005	.009	3	1
LARGE_INTESTINE	CPLX4 →	+0.020	+2.444	.002	.008	3	1
LARGE_INTESTINE	FBXW10 →	+0.202	+3.491	.002	.004	3	1
LARGE_INTESTINE	CALML5 →	+0.956	+3.215	<.001	.009	3	1
LARGE_INTESTINE	CENPVL1 →	+0.097	+2.832	.007	.002	3	1
LARGE_INTESTINE	SPEM3 →	+0.010	+2.669	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

SENP3 by NEUROD1 expression — LARGE_INTESTINE

Explore this box plot interactively →