NEURL1

Across TCGA patient cohorts, NEURL1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEURL1-associated genes across cancer lineages are Akt, XRCC1, and FoxM1. Each is linked with NEURL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEURL1-to-partner and partner-to-NEURL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt grouped by NEURL1-low versus NEURL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEURL1→partner) and Y-score (partner→NEURL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt →	-0.225	-2.990	.049	.036	3	2
SKCM	XRCC1 →	+0.211	+3.000	.037	.036	3	1
UCEC	FoxM1 →	+0.259	+2.321	.046	.035	3	1
UCEC	MEK1 →	+0.523	+3.459	.004	.005	3	1
UCEC	PDCD4 →	-0.716	-3.459	.002	.005	3	1
UCEC	Tuberin →	+0.315	+2.321	.019	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Akt by NEURL1 expression — UCEC

Explore this box plot interactively →