NEU2

Across TCGA cell cohorts, NEU2 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEU2-associated genes across cancer lineages are OR8B12, ODF1, and OR56A5. Each is linked with NEU2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEU2-to-partner and partner-to-NEU2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B12 grouped by NEU2-low versus NEU2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEU2→partner) and Y-score (partner→NEU2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR8B12 →	+0.032	+5.029	<.001	.006	3	2
OESOPHAGUS	ODF1 →	+0.996	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR56A5 →	+0.111	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR10C1 →	+0.066	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.045	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR12D1 →	+0.042	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

OR8B12 by NEU2 expression — LUNG_SCLC

Explore this box plot interactively →