NES

Across TCGA pan-cancer cohorts, NES Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated NES data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NES Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated NES expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, ACC, and BRCA are the cancer types where NES Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.974	0.615	.003	36	view →
ACC	DFS	Median	All	0.050	0.675	<.001	29	view →
BRCA	OS	Median	III,IV	0.200	0.833	<.001	16	view →
COAD	OS	Median	III,IV	0.150	0.787	<.001	16	view →
LUSC	DFS	Median	II,III,IV	0.254	0.620	<.001	15	view →
STAD	DFS	Median	III,IV	1.000	0.326	.015	11	view →
READ	DFS	Median	III,IV	0.082	0.746	<.001	6	view →
LIHC	OS	Median	All	0.255	0.709	.040	3	view →
SCLC	DFS	Median	All	0.794	0.441	.037	3	view →
SKCM	DFS	Median	II,III,IV	0.954	0.659	.012	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

NES–UCEC (DFS)

Open the UCEC breakdown →