NES

Across TCGA pan-cancer cohorts, NES RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of NES’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where NES RNA is repressed in tumor relative to normal tissue. In most cancer types NES is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and BLCA are the cancer types where NES tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NES RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	All	−2.989	<.001	11	view →
KICH	Male	II,III,IV	−2.792	<.001	11	view →
BLCA	Male	All	−1.812	<.001	11	view →
LIHC	Female	II,III,IV	+1.949	<.001	9	view →
LUAD	Male	All	−1.491	<.001	8	view →
LUSC	Female	II,III,IV	−2.577	<.001	7	view →
UCEC	All	All	−1.961	<.001	6	view →
BRCA	Female	II,III,IV	−1.596	<.001	6	view →
HNSC	Female	All	+1.480	.010	6	view →
CHOL	Male	All	+3.293	<.001	5	view →
KIRC	Male	All	−0.523	.002	5	view →
STAD	Male	II,III,IV	+1.095	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

NES–KIRP

Open the KIRP breakdown →