NES

Across TCGA patient cohorts, NES protein abundance is significantly associated with the RNA expression of many other genes, with 16,396 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NES-associated genes across cancer lineages are RHOJ, DENND2A, and SEPTIN4. Each is linked with NES in more than 8 cancer types. Because this analysis shows association rather than direction, both NES-to-partner and partner-to-NES results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NES versus RHOJ in GBM, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NES→partner) and Y-score (partner→NES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RHOJ →	+1.012	+0.551	<.001	<.001	3	9
OV	DENND2A →	+0.877	+0.454	<.001	<.001	3	9
CCRCC	SEPTIN4 →	+0.652	+0.421	<.001	<.001	3	8
CCRCC	FHL5 →	+1.175	+0.569	<.001	<.001	3	8
OV	CALD1 →	+1.203	+0.378	<.001	<.001	3	8
CCRCC	RAMP2 →	+1.070	+0.610	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,396 associations by consensus.

NES vs RHOJ — GBM

Explore this scatter interactively →