NES

Across TCGA patient cohorts, NES mutation is significantly associated with the RNA expression of many other genes, with 3,291 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NES-associated genes across cancer lineages are LARP1B, TPRKB, and RNU6-660P. Each is linked with NES in more than 3 cancer types. Because this analysis shows association rather than direction, both NES-to-partner and partner-to-NES results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LARP1B grouped by NES-low versus NES-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NES→partner) and Y-score (partner→NES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LARP1B →	+0.560	+3.212	<.001	.009	3	4
BRCA	TPRKB →	+0.464	+3.327	<.001	.006	3	4
BRCA	RNU6-660P →	+0.172	+4.623	<.001	<.001	3	4
UCEC	FAXDC2 →	-0.535	-2.652	<.001	<.001	3	4
UCEC	SLAMF7 →	+0.683	+1.651	.002	.001	3	4
UCEC	MSANTD3 →	+0.394	+1.964	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,291 associations by consensus.

LARP1B by NES expression — BLCA

Explore this box plot interactively →