NES

Across TCGA patient cohorts, NES mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NES-associated genes across cancer lineages are EGFR_pY1068, C-Raf, and INPP4B. Each is linked with NES in more than 2 cancer types. Because this analysis shows association rather than direction, both NES-to-partner and partner-to-NES results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NES-low versus NES-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NES→partner) and Y-score (partner→NES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EGFR_pY1068 →	+1.239	+2.814	<.001	.037	3	3
UCEC	C-Raf →	+0.131	+1.201	.003	.028	3	3
LUAD	INPP4B →	-0.467	-1.983	.010	.031	3	2
LUAD	PEA-15_pS116 →	-0.213	-3.000	.024	.035	3	2
LUAD	Transglutaminase →	-0.287	-2.000	.044	.031	3	2
LUAD	Chk1 →	+0.209	+2.459	.031	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

EGFR_pY1068 by NES expression — BRCA

Explore this box plot interactively →