NES

Across TCGA cell cohorts, NES RNA expression is significantly associated with the go_rna of many other GO terms, with 3,226 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NES-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Positive regulation of neuron migration. Each is linked with NES in more than 9 cancer types. Because this analysis shows association rather than direction, both NES-to-partner and partner-to-NES results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by NES-low versus NES-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NES→partner) and Y-score (partner→NES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.085	+1.396	.008	.009	3	10
BREAST	Negative regulation of myoblast fusion →	+0.064	+1.370	.003	.002	3	9
STOMACH	Positive regulation of neuron migration →	+0.085	+2.428	.002	<.001	3	8
LUNG_NSCLC_LUSC	Nucleoside triphosphate biosynthetic process →	+0.081	+2.931	.001	.003	2	8
PANCREAS	Positive regulation of telomere maintenance via telomerase →	+0.065	+1.646	<.001	<.001	3	7
LARGE_INTESTINE	Regulation of RNA splicing →	+0.068	+1.880	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,226 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by NES expression — URINARY_TRACT

Explore this box plot interactively →