NES

Across TCGA cell cohorts, NES mutation is significantly associated with the RNA expression of many other genes, with 672 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NES-associated genes across cancer lineages are DCLK3, LRIT2, and LRRC3C. Each is linked with NES in more than 1 cancer types. Because this analysis shows association rather than direction, both NES-to-partner and partner-to-NES results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCLK3 grouped by NES-low versus NES-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NES→partner) and Y-score (partner→NES) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DCLK3 →	+0.159	+3.769	.004	.008	3	2
BLOOD_Leukemia	LRIT2 →	+0.122	+4.362	<.001	.002	3	2
BLOOD_Leukemia	LRRC3C →	+0.095	+3.796	<.001	.008	3	2
LARGE_INTESTINE	DNAJA3 →	+0.593	+2.714	.001	.002	3	2
LUNG_NSCLC_LUAD	SPATA31D1 →	+0.002	+3.006	<.001	.005	3	2
BREAST	OR8A1 →	+0.165	+2.232	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 672 associations by consensus.

DCLK3 by NES expression — BLOOD_Leukemia

Explore this box plot interactively →