NEO1

Across TCGA patient cohorts, NEO1 mutation is significantly associated with the RNA expression of many other genes, with 6,290 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEO1-associated genes across cancer lineages are DTL, NUSAP1, and NEK2. Each is linked with NEO1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NEO1-to-partner and partner-to-NEO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DTL grouped by NEO1-low versus NEO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEO1→partner) and Y-score (partner→NEO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DTL →	+0.764	+2.275	<.001	<.001	3	5
UCEC	NUSAP1 →	+0.772	+1.906	<.001	<.001	3	5
UCEC	NEK2 →	+0.512	+1.368	.001	<.001	3	5
SKCM	HELLS →	+0.548	+3.334	.002	.005	3	4
UCEC	ZWINT →	+0.742	+2.415	<.001	<.001	3	4
UCEC	DLGAP5 →	+0.659	+1.769	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,290 associations by consensus.

DTL by NEO1 expression — UCEC

Explore this box plot interactively →