NEO1

Across TCGA pan-cancer cohorts, NEO1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NEO1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NEO1 RNA is repressed in tumor relative to normal tissue. In most cancer types NEO1 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and LUAD are the cancer types where NEO1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NEO1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.013	<.001	10	view →
THCA	All	II,III,IV	−0.699	<.001	9	view →
LUAD	Female	All	−0.776	<.001	6	view →
CHOL	Female	All	+3.289	<.001	5	view →
READ	All	All	−1.108	.006	4	view →
LIHC	Female	All	+1.074	<.001	4	view →
KICH	Male	All	−0.712	.016	4	view →
STAD	Male	II,III,IV	+0.913	.017	3	view →
UCEC	All	All	−0.643	.011	2	view →
PRAD	All	All	+0.284	.034	2	view →
STAD	Female	III,IV	−0.994	.023	1	view →
LUSC	All	All	+0.277	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

NEO1–COAD

Open the COAD breakdown →