NEO1

Across TCGA patient cohorts, NEO1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEO1-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and 4E-BP1. Each is linked with NEO1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NEO1-to-partner and partner-to-NEO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NEO1-low versus NEO1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEO1→partner) and Y-score (partner→NEO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+1.164	+3.000	<.001	.033	3	5
UCEC	PCNA →	+0.266	+2.087	<.001	<.001	3	3
STAD	4E-BP1 →	+0.333	+3.321	.017	.010	3	3
UCEC	MEK1 →	+0.399	+2.662	<.001	<.001	3	3
UCEC	S6_pS240_S244 →	+0.328	+1.652	.003	.005	3	3
UCEC	Cyclin-B1 →	+0.842	+2.321	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Caspase-7-cleavedD198 by NEO1 expression — STAD

Explore this box plot interactively →