NEO1

Across TCGA cell cohorts, NEO1 mutation is significantly associated with the RNA expression of many other genes, with 601 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEO1-associated genes across cancer lineages are DPRX, NUP88, and NEIL3. Each is linked with NEO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEO1-to-partner and partner-to-NEO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPRX grouped by NEO1-low versus NEO1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEO1→partner) and Y-score (partner→NEO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DPRX →	+0.050	+4.321	<.001	.009	3	2
LARGE_INTESTINE	NUP88 →	+0.790	+3.252	<.001	.002	3	2
LARGE_INTESTINE	NEIL3 →	+0.713	+3.237	.001	.003	3	2
LARGE_INTESTINE	ORC2 →	+0.513	+3.295	.001	.003	3	2
LARGE_INTESTINE	BBS7 →	+0.581	+3.386	.003	.001	3	2
LARGE_INTESTINE	CTDNEP1 →	+0.584	+3.502	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 601 associations by consensus.

DPRX by NEO1 expression — CNS

Explore this box plot interactively →