NENF

Across TCGA pan-cancer cohorts, NENF mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NENF data layer compared with 25 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NENF mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NENF expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where NENF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.264	0.886	.002	70	view →
PDAC	DFS	Quartile	II,III,IV	0.312	0.607	.011	11	view →
CCRCC	OS	Median	IV	1.000	0.202	.034	4	view →
LUAD	OS	Quartile	III,IV	0.458	1.000	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NENF–HNSC (DFS)

Open the HNSC breakdown →