NENF

Across TCGA pan-cancer cohorts, NENF RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of NENF’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NENF RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NENF is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KIRC, KICH, and LIHC are the cancer types where NENF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NENF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.530	<.001	11	view →
KICH	Female	II,III,IV	−2.059	<.001	9	view →
LIHC	Male	II,III,IV	+1.449	<.001	9	view →
HNSC	Male	II,III,IV	+0.611	<.001	9	view →
COAD	Female	II,III,IV	+0.930	<.001	8	view →
BRCA	All	All	+0.334	<.001	6	view →
CHOL	All	All	+1.776	<.001	5	view →
BLCA	Male	III,IV	−0.625	.007	4	view →
THCA	Male	All	−0.440	.002	4	view →
LUSC	All	All	+0.300	<.001	4	view →
ESCA	Male	All	+0.926	.029	2	view →
READ	All	All	+0.815	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

NENF–KIRC

Open the KIRC breakdown →