NELL1

Across TCGA patient cohorts, NELL1 mutation is significantly associated with the RNA expression of many other genes, with 7,347 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NELL1-associated genes across cancer lineages are CKAP2L, CHRNA5, and MCM6. Each is linked with NELL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NELL1-to-partner and partner-to-NELL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CKAP2L grouped by NELL1-low versus NELL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NELL1→partner) and Y-score (partner→NELL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CKAP2L →	+0.781	+2.180	<.001	<.001	3	4
HNSC	CHRNA5 →	+0.678	+3.204	.001	.009	3	4
UCEC	MCM6 →	+0.677	+3.643	<.001	<.001	3	4
UCEC	RANBP1 →	+0.494	+1.959	<.001	<.001	3	4
UCEC	PRC1 →	+0.911	+1.959	<.001	<.001	3	4
UCEC	HMGXB4 →	+0.543	+1.970	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,347 associations by consensus.

CKAP2L by NELL1 expression — UCEC

Explore this box plot interactively →