NELL1

Across TCGA pan-cancer cohorts, NELL1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated NELL1 data layer compared with 10 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher NELL1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NELL1 expression acts as an unfavorable survival marker, although some lineages such as UCS and HNSC show a favorable association.

LIHC, UCEC, and UCS are the cancer types where NELL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.549	0.733	<.001	76	view →
UCEC	DFS	Tertile	III,IV	0.353	0.663	.002	58	view →
UCS	DFS	Quartile	III,IV	0.748	0.133	.001	56	view →
HNSC	DFS	Quartile	IV	0.654	0.448	.002	45	view →
STAD	DFS	Tertile	All	0.201	0.503	.004	42	view →
DLBC	DFS	Tertile	All	1.000	0.378	.012	30	view →
GBM	OS	Tertile	All	0.289	0.482	<.001	24	view →
UVM	DFS	Median	III,IV	0.302	0.889	.007	16	view →
MESO	OS	Tertile	All	0.379	0.181	.012	14	view →
BLCA	DFS	Tertile	III,IV	0.173	0.411	.004	13	view →
LUSC	DFS	Tertile	III,IV	0.511	0.750	.011	11	view →
THCA	OS	Quartile	All	0.870	1.000	.025	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

NELL1–LIHC (OS)

Open the LIHC breakdown →