NELL1

Across TCGA patient cohorts, NELL1 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NELL1-associated genes across cancer lineages are MYH11, Bcl-2, and Collagen-VI. Each is linked with NELL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NELL1-to-partner and partner-to-NELL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH11 grouped by NELL1-low versus NELL1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NELL1→partner) and Y-score (partner→NELL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MYH11 →	-1.035	-1.990	.006	.031	3	3
LUSC	Bcl-2 →	-0.382	-3.156	.010	.018	3	3
LUSC	Collagen-VI →	-0.252	-3.169	.036	.018	3	3
SKCM	CD49b →	+0.187	+1.874	.019	.047	3	3
COAD	G6PD →	+0.207	+2.330	.015	.020	3	3
UCEC	ACC1 →	+0.299	+2.235	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

MYH11 by NELL1 expression — LUSC

Explore this box plot interactively →