NELL1

Across TCGA cell cohorts, NELL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,391 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NELL1-associated GO terms across cancer lineages are Regulation of termination of RNA polymerase II transcription, Regulation of termination of DNA-templated transcription, and Regulation of transcription initiation by RNA polymerase II. Each is linked with NELL1 in more than 6 cancer types. Because this analysis shows association rather than direction, both NELL1-to-partner and partner-to-NELL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of termination of RNA polymerase II transcription grouped by NELL1-low versus NELL1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NELL1→partner) and Y-score (partner→NELL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of termination of RNA polymerase II transcription →	+0.111	+2.169	<.001	.001	3	7
SOFT_TISSUE	Regulation of termination of DNA-templated transcription →	+0.111	+2.169	<.001	.001	3	7
BONE	Regulation of transcription initiation by RNA polymerase II →	+0.058	+0.826	.002	.001	3	7
SOFT_TISSUE	Negative regulation of gene expression, epigenetic →	+0.049	+2.133	<.001	<.001	3	6
SOFT_TISSUE	Regulation of DNA repair →	+0.044	+1.720	<.001	<.001	3	6
BONE	Heterochromatin organization →	+0.066	+0.709	.003	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,391 associations by consensus.

Regulation of termination of RNA polymerase II transcription by NELL1 expression — SOFT_TISSUE

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