NELL1

Across TCGA cell cohorts, NELL1 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NELL1-associated genes across cancer lineages are MAGEB4, MOS, and CNBD1. Each is linked with NELL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NELL1-to-partner and partner-to-NELL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by NELL1-low versus NELL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NELL1→partner) and Y-score (partner→NELL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	2
BLOOD_Myeloma	MOS →	+0.040	+4.807	<.001	.006	3	1
SOFT_TISSUE	CNBD1 →	+0.242	+4.882	<.001	.001	3	1
SOFT_TISSUE	VCX2 →	+0.107	+4.635	<.001	.003	3	1
SOFT_TISSUE	FTMT →	+0.065	+4.977	<.001	.002	3	1
SOFT_TISSUE	CT83 →	+0.998	+4.635	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

MAGEB4 by NELL1 expression — LARGE_INTESTINE

Explore this box plot interactively →