Across TCGA patient cohorts, NELFA mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NELFA-associated genes across cancer lineages are STAT3_pY705, Cyclin-B1, and eIF4E. Each is linked with NELFA in more than 1 cancer types. Because this analysis shows association rather than direction, both NELFA-to-partner and partner-to-NELFA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NELFA→partner) and Y-score (partner→NELFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.270	-1.874	.005	.049	3	2
UCEC	Cyclin-B1 →	+0.552	+1.765	.008	.014	3	2
UCEC	eIF4E →	+0.181	+2.169	.022	.003	3	1
UCEC	A-Raf_pS299 →	-0.113	-2.700	.011	.006	3	1
UCEC	ERK2 →	+0.144	+2.999	.046	.035	3	1
UCEC	FoxM1 →	+0.234	+1.415	.016	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

NELFA survival (RNA) · tumor vs normal (RNA) · all NELFA data types