NELFA

mutation — cross-omics
Cross-omicsMUTATION → RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, NELFA mutation is significantly associated with the RNA expression of many other genes, with 1,451 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NELFA-associated genes across cancer lineages are PMM1, DDHD1, and MTFMT. Each is linked with NELFA in more than 1 cancer types. Because this analysis shows association rather than direction, both NELFA-to-partner and partner-to-NELFA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NELFA→partner) and Y-score (partner→NELFA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LARGE_INTESTINEPMM1 →+0.569+3.169.004.00932
LARGE_INTESTINEDDHD1 →+0.825+3.628<.001<.00132
LARGE_INTESTINEMTFMT →+0.484+2.502.006.00532
LARGE_INTESTINEINTS9 →+0.567+2.502.001.00532
LARGE_INTESTINELRRFIP1 →+0.584+2.502.003.00532
LARGE_INTESTINEPEX1 →+0.487+2.502.002.00532
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,451 associations by consensus.

Exploration