NEK8

Across TCGA pan-cancer cohorts, NEK8 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NEK8 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NEK8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NEK8 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where NEK8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.887	0.283	.012	11	view →
LUAD	OS	Median	III,IV	1.000	0.827	.016	6	view →
HNSC	DFS	Quartile	II,III,IV	0.805	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NEK8–CCRCC (DFS)

Open the CCRCC breakdown →