NEK8

Across TCGA pan-cancer cohorts, NEK8 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NEK8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NEK8 RNA is repressed in tumor relative to normal tissue. In most cancer types NEK8 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, COAD, and BRCA are the cancer types where NEK8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NEK8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.478	<.001	11	view →
COAD	Female	All	+0.748	<.001	10	view →
BRCA	All	All	+0.352	<.001	8	view →
BLCA	All	III,IV	+1.027	.001	7	view →
LIHC	Female	II,III,IV	+1.002	<.001	7	view →
STAD	All	II,III,IV	+0.873	<.001	7	view →
KIRP	All	II,III,IV	+0.661	.010	6	view →
CHOL	Male	All	+1.503	<.001	5	view →
KIRC	All	II,III,IV	−0.268	.011	4	view →
ESCA	All	II,III,IV	+1.374	.008	2	view →
READ	Female	All	+1.132	.002	2	view →
UCEC	All	All	+0.553	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NEK8–KICH

Open the KICH breakdown →