NEK8

Across TCGA patient cohorts, NEK8 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,426 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NEK8-associated proteins across cancer lineages are SMC3, HNRNPLL, and SUPT6H. Each is linked with NEK8 in more than 5 cancer types. Because this analysis shows association rather than direction, both NEK8-to-partner and partner-to-NEK8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NEK8 versus SMC3 in GBM, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK8→partner) and Y-score (partner→NEK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC3 →	+0.259	+0.332	<.001	<.001	3	6
HNSC	HNRNPLL →	+0.285	+0.691	<.001	<.001	3	6
BRCA	SUPT6H →	+0.301	+0.757	<.001	<.001	3	6
OV	PARN →	+0.361	+0.515	<.001	<.001	3	6
GBM	SMC1A →	+0.274	+0.343	<.001	<.001	3	6
GBM	XRCC1 →	+0.282	+0.280	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,426 associations by consensus.

NEK8 vs SMC3 — GBM

Explore this scatter interactively →