NEK8

Across TCGA patient cohorts, NEK8 protein abundance is significantly associated with the RNA expression of many other genes, with 6,586 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible NEK8-associated genes across cancer lineages are RPL9P2, CDRT4, and SERPINE1. Each is linked with NEK8 in more than 3 cancer types. Because this analysis shows association rather than direction, both NEK8-to-partner and partner-to-NEK8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NEK8 versus RPL9P2 in UCEC, with a Pearson correlation of 0.77.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK8→partner) and Y-score (partner→NEK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL9P2 →	+1.225	+0.606	.006	.001	3	3
UCEC	CDRT4 →	+1.165	+0.596	.002	.001	3	3
LSCC	SERPINE1 →	-1.213	-0.271	<.001	<.001	3	3
BRCA	RABGAP1 →	+0.428	+0.565	.001	.002	3	3
CCRCC	SNAI1 →	-0.730	-0.370	<.001	<.001	3	3
LSCC	TRMO →	+0.452	+0.339	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,586 associations by consensus.

NEK8 vs RPL9P2 — UCEC

Explore this scatter interactively →