NEK8

Across TCGA patient cohorts, NEK8 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK8-associated genes across cancer lineages are PCNA, ATM, and 4E-BP1_pT37_T46. Each is linked with NEK8 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK8-to-partner and partner-to-NEK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by NEK8-low versus NEK8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK8→partner) and Y-score (partner→NEK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.240	+2.736	.002	<.001	3	2
UCEC	ATM →	-0.452	-2.102	.006	.016	3	2
UCEC	4E-BP1_pT37_T46 →	-0.441	-3.687	.001	.001	3	2
UCEC	A-Raf_pS299 →	-0.101	-2.584	.021	.010	3	1
UCEC	ERK2 →	+0.159	+2.222	.025	.009	3	1
UCEC	JNK2 →	+0.234	+2.247	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

PCNA by NEK8 expression — UCEC

Explore this box plot interactively →