NEK8

Across TCGA cell cohorts, NEK8 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NEK8-associated genes across cancer lineages are IL22, LRRC72, and MYOCD. Each is linked with NEK8 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK8-to-partner and partner-to-NEK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL22 grouped by NEK8-low versus NEK8-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK8→partner) and Y-score (partner→NEK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	IL22 →	+0.035	+4.285	<.001	.007	3	1
STOMACH	LRRC72 →	+0.070	+4.285	<.001	.007	3	1
BLOOD_Leukemia	MYOCD →	+0.783	+3.845	.001	<.001	3	1
BLOOD_Leukemia	TENM2 →	+0.460	+3.362	<.001	.007	3	1
BLOOD_Leukemia	ZIC3 →	+0.012	+3.890	<.001	<.001	3	1
BLOOD_Leukemia	FRG2C →	+0.246	+3.812	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

IL22 by NEK8 expression — STOMACH

Explore this box plot interactively →