NEK2

Across TCGA patient cohorts, NEK2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,122 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible NEK2-associated genes across cancer lineages are SEC14L2, PVALB, and FKBP3. Each is linked with NEK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK2-to-partner and partner-to-NEK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NEK2 versus SEC14L2 in BRCA, with a Pearson correlation of -0.70.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK2→partner) and Y-score (partner→NEK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEC14L2 →	-1.877	-0.666	.001	.002	3	1
BRCA	PVALB →	-2.458	-0.723	.004	.002	3	1
BRCA	FKBP3 →	-1.326	-0.882	<.001	<.001	3	1
BRCA	COCH →	+1.784	+0.879	.002	<.001	3	1
BRCA	CGRRF1 →	-1.097	-0.757	.003	.001	3	1
BRCA	SAMD15 →	-2.828	-0.779	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,122 associations by consensus.

NEK2 vs SEC14L2 — BRCA

Explore this scatter interactively →