NEK1

Across TCGA pan-cancer cohorts, NEK1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NEK1 data layer compared with 24 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NEK1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NEK1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, LSCC, and OV are the cancer types where NEK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.885	0.727	.013	8	view →
LSCC	OS	Tertile	II,III,IV	0.684	0.919	.014	6	view →
OV	DFS	Median	All	0.576	0.864	.031	4	view →
GBM	DFS	Tertile	All	0.254	0.449	.047	2	view →
HNSC	OS	Median	II,III,IV	0.952	1.000	.016	2	view →
PDAC	OS	Median	II,III,IV	0.273	0.471	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NEK1–CCRCC (DFS)

Open the CCRCC breakdown →