NEK1

Across TCGA patient cohorts, NEK1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEK1-associated genes across cancer lineages are PKC-b-II_pS660, eEF2, and JNK_pT183_Y185. Each is linked with NEK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NEK1-to-partner and partner-to-NEK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by NEK1-low versus NEK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK1→partner) and Y-score (partner→NEK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-b-II_pS660 →	-0.205	-1.440	.024	.022	3	3
UCEC	eEF2 →	+0.256	+2.459	.030	.018	3	2
UCEC	JNK_pT183_Y185 →	-0.200	-2.906	<.001	.001	3	2
UCEC	Notch1 →	+0.218	+2.515	<.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.410	-2.000	.005	.009	3	2
UCEC	PDCD4 →	-0.599	-2.160	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PKC-b-II_pS660 by NEK1 expression — UCEC

Explore this box plot interactively →