NEK1

Across TCGA cell cohorts, NEK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,068 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NEK1-associated GO terms across cancer lineages are DNA damage tolerance, DNA alkylation repair, and Regulation of maintenance of sister chromatid cohesion. Each is linked with NEK1 in more than 14 cancer types. Because this analysis shows association rather than direction, both NEK1-to-partner and partner-to-NEK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA damage tolerance grouped by NEK1-low versus NEK1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK1→partner) and Y-score (partner→NEK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DNA damage tolerance →	+0.107	+0.633	<.001	.002	3	15
STOMACH	DNA alkylation repair →	+0.146	+0.920	<.001	<.001	3	15
STOMACH	Regulation of maintenance of sister chromatid cohesion →	+0.099	+0.971	<.001	<.001	3	15
STOMACH	Regulation of maintenance of mitotic sister chromatid cohesion →	+0.099	+0.971	<.001	<.001	3	15
LUNG_SCLC	Regulation of microtubule cytoskeleton organization →	+0.089	+0.627	<.001	.002	3	14
LUNG_NSCLC_LUSC	Positive regulation of organelle assembly →	+0.056	+0.815	.005	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,068 associations by consensus.

DNA damage tolerance by NEK1 expression — LUNG_SCLC

Explore this box plot interactively →