NEK1

Across TCGA cell cohorts, NEK1 mutation is significantly associated with the RNA expression of many other genes, with 141 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEK1-associated genes across cancer lineages are OR13D1, CXorf49B, and CXorf49. Each is linked with NEK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEK1-to-partner and partner-to-NEK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13D1 grouped by NEK1-low versus NEK1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEK1→partner) and Y-score (partner→NEK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR13D1 →	+0.016	+3.977	<.001	.007	3	2
SOFT_TISSUE	CXorf49B →	+0.659	+3.142	.001	.008	3	2
SOFT_TISSUE	CXorf49 →	+0.472	+3.295	<.001	.006	3	2
LUNG_NSCLC_LUSC	WFDC13 →	+0.069	+3.502	.001	.002	3	2
BLOOD_Leukemia	PRM2 →	+0.033	+4.384	<.001	.006	3	2
BLOOD_Leukemia	NANOS2 →	+0.052	+4.133	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 141 associations by consensus.

OR13D1 by NEK1 expression — SOFT_TISSUE

Explore this box plot interactively →