NEIL3

Across TCGA patient cohorts, NEIL3 mutation is significantly associated with the RNA expression of many other genes, with 3,392 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEIL3-associated genes across cancer lineages are MRPS30, KIF19, and ATP5MGP1. Each is linked with NEIL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NEIL3-to-partner and partner-to-NEIL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS30 grouped by NEIL3-low versus NEIL3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEIL3→partner) and Y-score (partner→NEIL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MRPS30 →	+0.581	+3.341	.004	.005	3	3
UCEC	KIF19 →	-0.855	-2.898	.003	.001	3	3
UCEC	ATP5MGP1 →	-0.380	-1.792	.001	.008	3	3
LUSC	EIF3D →	+0.422	+3.459	.006	.005	3	3
UCEC	SSRP1 →	+0.499	+2.960	<.001	<.001	3	3
UCEC	CCT5 →	+0.622	+2.389	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,392 associations by consensus.

MRPS30 by NEIL3 expression — SKCM

Explore this box plot interactively →