NEIL3

Across TCGA pan-cancer cohorts, NEIL3 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of NEIL3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NEIL3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NEIL3 is over-expressed in tumor.

HNSC, LUAD, and BLCA are the cancer types where NEIL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NEIL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+1.449	<.001	12	view →
LUAD	Male	II,III,IV	+2.260	<.001	11	view →
BLCA	All	All	+1.431	<.001	11	view →
COAD	Male	III,IV	+1.181	<.001	11	view →
KIRC	Male	IV	+1.008	<.001	11	view →
LUSC	All	III,IV	+2.816	<.001	9	view →
KIRP	Male	III,IV	+1.681	<.001	9	view →
LIHC	Male	II,III,IV	+1.301	<.001	9	view →
UCEC	All	III,IV	+2.483	<.001	8	view →
STAD	Female	All	+1.795	<.001	8	view →
BRCA	All	III,IV	+1.743	<.001	6	view →
KICH	Male	II,III,IV	+0.937	.025	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

NEIL3–HNSC

Open the HNSC breakdown →