NEIL3

Across TCGA patient cohorts, NEIL3 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEIL3-associated genes across cancer lineages are Annexin-1, Caspase-7-cleavedD198, and Rb_pS807_S811. Each is linked with NEIL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NEIL3-to-partner and partner-to-NEIL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by NEIL3-low versus NEIL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEIL3→partner) and Y-score (partner→NEIL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.558	+2.341	.002	.003	3	3
UCEC	Caspase-7-cleavedD198 →	+0.518	+2.341	.013	.003	3	3
LUSC	Rb_pS807_S811 →	+0.413	+2.179	.045	.035	3	2
UCEC	ACC1 →	+0.367	+2.000	.004	.003	3	2
UCEC	Notch1 →	+0.161	+2.128	.001	.009	3	2
UCEC	PCNA →	+0.177	+1.700	.020	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Annexin-1 by NEIL3 expression — UCEC

Explore this box plot interactively →