NEIL3

Across TCGA cell cohorts, NEIL3 mutation is significantly associated with the RNA expression of many other genes, with 397 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NEIL3-associated genes across cancer lineages are CD300E, IFNA17, and NKX2-6. Each is linked with NEIL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEIL3-to-partner and partner-to-NEIL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD300E grouped by NEIL3-low versus NEIL3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEIL3→partner) and Y-score (partner→NEIL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CD300E →	+0.046	+5.807	<.001	.001	3	1
OVARY	IFNA17 →	+0.020	+5.807	<.001	.001	3	1
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1
LARGE_INTESTINE	GCAT →	+1.346	+3.169	<.001	.009	3	1
LARGE_INTESTINE	CBY1 →	+0.667	+3.307	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 397 associations by consensus.

CD300E by NEIL3 expression — OVARY

Explore this box plot interactively →