NEIL1

Across TCGA patient cohorts, NEIL1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NEIL1-associated genes across cancer lineages are Rad50, ATM, and p27_pT198. Each is linked with NEIL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NEIL1-to-partner and partner-to-NEIL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by NEIL1-low versus NEIL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NEIL1→partner) and Y-score (partner→NEIL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.346	-2.459	.003	.020	3	2
UCEC	ATM →	-0.481	-2.986	.028	.035	3	2
UCEC	p27_pT198 →	+0.113	+2.459	.029	.020	3	1
UCEC	p62 Lck ligand →	+0.405	+2.179	.009	.034	3	1
UCEC	Rab25 →	-0.340	-3.169	.034	.019	3	1
UCEC	Annexin-1 →	+0.736	+3.019	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Rad50 by NEIL1 expression — UCEC

Explore this box plot interactively →